Positive interactions between STAP-1 and BCR-ABL influence chronic myeloid leukemia cell proliferation and survival

BCR-ABL fusion genes and laboratory findings in patients with chronic myeloid leukemia in northeast Iran

Background: A specific chromosomal abnormality, the Philadelphia chromosome (BCR-ABL fusion), is present in all patients with chronic myeloid leukemia (CML). The b2a2 and b3a2 fusion mRNAs encode p210 fusion protein p210 and e1a2 encode p190. The aim of this study was to evaluate the frequency of BCR-ABL fusion transcript variants in Northeast of Iranian CML patients and to compare the laborato...

Frequency of BCR-ABL Fusion Transcripts in Iranian Azeri Turkish patients with Chronic Myeloid Leukemia

Background: The Philadelphia chromosome (Ph) characterized by t (9; 22) (q34; q11.2) is a reciprocal translocation giving rise to a chimeric BCR-ABL fusion gene. Incidence of Ph chromosome is over 98% in Patients with Chronic Myeloid Leukemia (CML) and around 20% in acute lymphoblastic leukemia (ALL). The finding of this fusion gene is essential for diagnosis of CML by detection of various fusi...

Inhibition of Cholesterol Esterfication and Bcr-Abl Synergistically Suppresses Proliferation of Chronic Myeloid Leukemia with Bcr-Abl Independent Imatinib

Listeria monocytogenes (LM) is a Gram-positive bacterium, ubiquitous in nature and is associated with foodborne illness transmitted by produce and processed meat and dairy products. Incidence rates of listeriosis are relatively low, however, the morbidity of the disease is disproportionately high in pregnant women and their fetuses often manifesting as meningoencephalitis or spontaneous abortio...

BCR-ABL breakpoint and prognosis in chronic myeloid leukemia.

BCR/ABL mRNA targeting small interfering RNA effects on proliferation and apoptosis in chronic myeloid leukemia.

BACKGROUND To investigate the effects of small interference RNA (siRNA) targeting BCR/ABL mRNA on proliferation and apoptosis in the K562 human chronic myeloid leukemia (CML) cell line and to provide a theoretical rationale and experimental evidence for its potential clinical application for anti-CML treatment. MATERIALS AND METHODS The gene sequence for BCR/ABL mRNA was found from the GeneBa...